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Dr. Ross > Health > New Weight Loss Drugs Target the Endocannabinoid System

New Weight Loss Drugs Target the Endocannabinoid System

By: Michele Ross, PhD · Published On: August 18, 2020 · Last Updated: October 19, 2022

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The endocannabinoid system is involved in many pathways in the body, including regulation of appetite and fat burning. Anyone who has experienced “the munchies” can attest to the fact that many cannabis strains and edibles with THC can increase hunger. Hunger is increased by activating the endocannabinoid system, and thus scientists thought blocking the endocannabinoid system with drugs could decrease hunger and increase weight loss.

The Opposite of The Munchies

Rimonabant was a first-generation inhibitor of cannabinoid type 1 (CB1) receptors, working both in the brain and the body. It was first approved in Europe in 2006 and was taken off the market in 2008 due to psychiatric side effects in 10% of patients including suicidal thoughts that outweighed its medical benefits as a weight loss drug. It was never approved as a drug in the United States.

read vitamin weed by dr michele ross neuroscientist

A second-generation of CB1 inhibitors have been developed, this time working only on peripheral cannabinoid receptors and not crossing the blood-brain barrier. These second-generation drugs, like AM6545, do not have the same psychiatric side effects rimonabant does but reduce elevated metabolic parameters including cholesterol and insulin.

Rimonabant also induced nausea and vomiting, while AM6545 has minimal nausea side effects. AM6545 only decreased weight in mice that are obese due to a high-fat diet, and not normal mice. This is important because it shows CB1 inhibitors will not be abused by normal weight or underweight patients looking to drop 10 pounds in a week.

It may take many years for these drugs to show efficacy in human clinical trials and be approved as a prescription by the United States Food & Drug Administration, or FDA. Until then, other cannabinoids including CBD and THCV have shown efficacy in weight loss and are available in many hemp and cannabis products.

References

Tam, J., et al., Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest, 2010. 120(8): p. 2953-66.

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New Weight Loss Drugs Target the Endocannabinoid System
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By: Michele Ross, PhD · In: Health · Tagged: CBD, cholesterol, clinical research, FDA, weight loss

plant medicine expert neuroscientist Dr. Michele Ross

About Michele Ross, PhD

Dr. Michele Ross is a neuroscientist helping women heal chronic pain with CBD, cannabis, kratom, and mushrooms. She is the author of Kratom is Medicine, Vitamin Weed and CBD Oil For Health.

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Happy International Women's Day to all the women c Happy International Women's Day to all the women crushing it despite getting less pay, less startup funding, less everything when it comes to business. Let's do more than recognize women.
In 2023, it's time to:
*Buy from women-owned businesses
*Give women a seat at the table, preferably the board
*End all male speaking panels
*Invest in women startups, including those focused on serving women
*Include more women in clinical trials
*End toxic work cultures
*Support paid maternity leave policies
*Fill the wage gap between men and women
*Donate to nonprofits serving women
*Let women take time off of work for painful periods without stigma or penalty
*Work harder to specifically include and apply all of these principles to women from marginalized groups such as black women, disabled women, LGBTQ women, and females identifying as nonbinary, genderfluid, or genderqueer.
And so. much. more.
#internationalwomensday #womensday2023 #internationalwomensday2023 #womenfounders
#investinwomen
No one is giving $2 w🌱🌱d gummies to children No one is giving $2 w🌱🌱d gummies to children trick or treating on Halloween. Those reports you hear on the news simply aren’t true! ⁣
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However, if you are attending a Halloween party for adults, ask if the candies, goodies, or drinks are special or infused! Edibles are more common at parties as an alternative to alcohol, especially in states where the plant has been legalized for both recreational & medical use.⁣
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If you’re not used to consuming, try a small piece or half a piece, drink plenty of water, and make sure you have a safe place to sit if needed. And always call a rideshare aka Uber or Lyft home!⁣
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Happy Halloween! 🎃💀👻⁣
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#halloweencostume #halloween #halloweencostumes #halloweenparty #halloweenpartyideas #halloweenpartyideas🎃 #besafeoutthere #parentingmemes #halloweed #microdosing #cannamom #halloweencandy #gummybear #trickrtreat
Happy National Mushr00m Day! 🍄 ⁣ Which is you Happy National Mushr00m Day! 🍄
⁣
Which is your favorite Medicinal Mushr00m?⁣⁣
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It's more important than ever to take mushr00m supplements. Here's a little about how my favorite four mushr00ms work:⁣⁣
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Lion’s Mane Mushr00ms: great for improving focus and memory. Lion's mane promotes neurogenesis, or birth of new brain cells.⁣⁣
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Cordyceps Mushr00ms: great for fighting fatigue and increasing length of your workouts. It's especially helpful for fibromyalgia and chronic fatigue patients.⁣⁣
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Turkey Tail Mushr00ms: great for supporting your immune system. Clinical trials have looked at its role in fighting cancer.⁣⁣
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Reishi Mushr00ms: what can't the queen of mushr00ms do? It fights cancer, boosts the immune system, improves mood, levels blood sugar, and promotes heart health.⁣⁣
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#cordyceps #reishi #reishimushroom #lionsmane #lionsmanemushrooms #lionsmanemushroom #turkeytail #turkeytailmushrooms #turkeytailmushroom #plantmedicine #medicinalmushrooms #shroomstagram #mushroomsociety #shroomies #functionalmushrooms #shrooms🍄 #mushrooms🍄
9/20 is National Magic Mushr00m Day. Why have a da 9/20 is National Magic Mushr00m Day. Why have a day to celebrate them?
Well in the United States & many parts of the world, they are still illegal, similar to another misunderstood therapeutic green plant we celebrate on 4/20. 
I've worked hard over the years in Denver & many other states to help decriminalize shr00ms and help people access information on how to use them for medical, spiritual, and stress relief purposes. I suggest following @decriminalizenature & @doubleblindmag for deeper info.
How are you celebrating today? ❤️ 🍄 ❤️
#fungilover #mushroomlover #psychedelictherapy #explorenature #natureistherapy
I’m not the only one, right? 😜 👩🏻‍🔬 💚
As a neuroscientist, I put out the first book on the potential causes of endocannabinoid deficiency and how to balance your ECS with or without plant medicine. 
From stress to medications to diet to your genes, there are so many ways your ECS go go haywire. The fact that so many people respond to plant medicine is likely because so many of us have severe imbalances.
Want to learn more, including what many of these terms mean? Check out my books (including Vitamin Weed) & courses via the link in my bio. 
#sciencelover #cannabiseducation #cannabisscience #lovelanguage #lovelanguages

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